Sarnia police seized drugs and a weapon from a Campbell St. home on Thursday.
Officers say they recovered a unsafely stored, unloaded .22 caliber rifle, ammunition, 25 x 100 mcg fentanyl patches and 21.3 g of crystal methamphetamine.
The total street value of the drugs seized is about $22,100.
Two men from Sarnia are charged with numerous firearms related offences, criminal code offences, and possession for the purpose of trafficking fentanyl and crystal methamphetamine.
James Fitzpatrick, 25, and Jacob Garvin, 26, are remanded in custody awaiting a bail hearing.