South Bruce OPP closed Hwy 21 in Kincardine on Tuesday afternoon due to a multi-vehicle collision.
The roadway did not re-open officially until just after 4 a.m. on Wednesday.
According to a spokesperson for the OPP, the collision involved four vehicles and three people were taken to hospital.
According to witnesses, Ornge helicopters responded. Police confirmed two people sustained life-threatening injuries, while another person sustained serious injuries.
The collision is under investigation.
A spokesperson for Bluewater District School Board said the second wave of buses for Kincardine Township-Tiverton Public School were impacted by road the closure, and arrangements were made at the time with families for student pickups.
More information to come.
