Indian Line was closed by Ontario Provincial Police (OPP) between Cemetery Road and Concession 2 following a collision.
Emergency crews responded to the crash just after 10:30 p.m. on Friday.
According to police, a male pedestrian was hit by a vehicle and suffered serious, life-threatening injuries. The man was transported to hospital where he was pronounced dead.
The name of the deceased person is not being released pending notification to the next of kin.
The driver of the vehicle remained on scene following the incident and did not suffer any injuries.
The investigation is ongoing.
Anyone with information is asked to contact the OPP at 1-888-310-1122 or Crime Stoppers at 1-800-222-8477 (TIPS).